3 December 2024 In-person, BMA House, London Driving real-world impact from health research

Steve Gentleman

Scientific Director, Imperial College London, UK

Over the past 30 years Steve has run an active research team investigating the neuropathology of neurodegenerative diseases and of traumatic brain injury. He is the Scientific Director of the Parkinson’s UK brain bank at Imperial College London and has extensive experience of brain banking and has worked with colleagues across the world on developing consensus criteria for the diagnosis of Parkinson’s disease (PD) and related disorders. Having contributed to the diagnostic assessment of over 1000 brains, he has a long-standing interest in the pathological basis for the non-motor symptoms of PD. To aid these studies, over the past 5 years, his team have been developing the Fast Clear technique for making brain tissue transparent to allow 3D visualisation of complex anatomical circuitry and pathology. In some of his earlier work, his team identified pathological changes in the brains of people who had died of a serious head injury which were very similar to those seen in the early stages of Alzheimer’s disease. More recently, his focus has been more on the emerging concept of the tauopathy known as chronic traumatic encephalopathy (CTE), particularly with respect to boxers and those who play other contact sports. In addition to his research interests, Steve is the Director of Education for the Department of Brain Sciences and plays an active role in the management and delivery of undergraduate and postgraduate courses.